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OpenTrials
Completed

NCT Number: NCT05249413

Early Vitrectomy for Endophthalmitis After Cataract Surgery

Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness. Acute post-operative endophthalmitis usually presented within 6 weeks of intraocular procedure and diagnosis is confirmed by clinical examination and by the aid of B-scan ultrasonography.

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Key information

Conditions

Endophthalmitis Cataract Eye Diseases Eye Infections Infections Lens Diseases Retinal Detachment Retinal Diseases Vitreous Detachment

Age range

3 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ophthalmology department, Benha University, EGYPT

Banhā, 13511, Egypt

About this study

There is no consensus regarding the timing of vitrectomy in cases with endophthalmitis after cataract surgery. The Endophthalmitis Vitrectomy Study concluded that vitrectomy should be preserved for cases with only light perception. The advances in posterior segment machines and small gauge cannulas decrease the incidence of intra-operative complications and encourage for early intervention in cases with endophthalmitis after primary cataract surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute onset endophthalmitis within 6 weeks after primary cataract surgeries.
  • Patients had undergone early pars-plana vitrectomy within 48 hours of their confirmed diagnosis.

Exclusion criteria

  • Patients were diagnosed as endogenous or chronic endophthalmitis.
  • Patients with a previous history of rupture globe surgery or trauma.
  • Patients who didn't complete the follow up period.

Treatment and study plan

Early 23-gauge pars-plana vitrectomy

Procedure

pars-plana vitrectomy for management of acute post-operative endophthalmitis.

Primary outcomes

  1. Best-corrected visual acuity

    Time frame: Baseline and 3 months after intervention.

    Changes in visual acuity from baseline and after early vitrectomy operation.

Secondary outcomes

  1. Other prognostic factors

    Time frame: Baseline and 3 months after intervention.

    Other factors that may influence the final visual outcome in cases with endophthalmitis as (intraocular tamponade, posterior vitreous detachment, systemic condition and virulence of causative organism)

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Outcomes of Early Vitrectomy for Endophthalmitis After Cataract Surgery in Delta Population, Egypt, 2015-2020.

Important dates

Study start
2015
Primary completion
2020
Study completion
2022
First posted
Feb 21, 2022
Registry last updated
Feb 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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