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Recruiting

NCT Number: NCT06520982

Early Neurovascular Adaptations in Aging Women

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Recruiting

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Key information

Conditions

Women Aging Blood Flow Sympathetic Nervous System

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Missouri-Columbia

Columbia, Missouri, 65211, United States

Location status: Recruiting

Location contact

Jacqueline K Limberg, Ph.D.

CONTACT

[email protected]

573-882-2420

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Assigned female at birth (AFAB)
  • 18-70 years of age

Exclusion criteria

  • Assigned male at birth (AMAB)
  • Pregnancy, breastfeeding
  • Body mass index ≥30 kg/m2
  • Taking medications known to affect metabolic, autonomic, and/or respiratory function
  • Oral hormonal contraception in last 6 month
  • History of hormone replacement therapy
  • History of hyster- or oophor-ectomy
  • Current smoking/Nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Chronic disease
  • Blood pressure ≥140/90 mmHg
  • Communication barriers

Treatment and study plan

norepinephrine

Drug

Infused intra-arterially in a dose-response fashion

Isoproterenol

Drug

Infused intra-arterially in a dose-response fashion

Acetylcholine

Drug

Infused intra-arterially in a dose-response fashion

nitroprusside

Drug

Infused intra-arterially in a dose-response fashion

Estrogen

Drug

Infused intra-arterially

Primary outcomes

  1. Magnitude of forearm blood flow

    Time frame: Change from baseline during infusion

Study contacts

Contact information is provided by the study sponsor or research team.

Jacqueline K Limberg

CONTACT

[email protected]

573-882-2420

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Collaborators

  • American Heart Association

Registry information

Important dates

Study start
2024
Primary completion
2027
Study completion
2028
First posted
Jul 25, 2024
Registry last updated
Nov 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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