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Completed

NCT Number: NCT01979770

Early Life Nutritional Exposures and Long-term Health and Cognitive Outcomes

This study aims to investigate the relationship of the various exposures during infancy and childhood on later health and development of adolescents. Various exposures to be assessed include, but not limit to, nutritional status, body composition, energy expenditure, dietary intake, micronutrient status, breastfeeding, lifestyle, and other environment exposures.

The study will specifically aim to respond these research questions:

1.1 What are the factors associated with overweight, obesity, and stunted in adolescents? 1.2 What are the factors associated with increased risk of NCDs during adolescence? 1.3 What are the factors associated with cognitive functioning during adolescence? Since numerous variables were collected, additional research questions can be possibly studied or other interested variables can be included in the future.

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Key information

Conditions

Overnutrition Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Undernutrition

Age range

13 year–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Nutrition, Mahidol University

Salaya, Changwat Nakhon Pathom, 73170, Thailand

About this study

A longitudinal data were collected in children in the northeast of Thailand beginning at 4-6 months of age and every 2 months through 10-12 months of age while children had been given iron and/or zinc supplementation. Biochemical, anthropometric, socio-demographic, feeding practices, and maternal characteristics data were collected. Children were followed up at 9 years of age to assess the long-term consequences of supplementation and early life nutrition on cognitive functioning and growth. There is a need to continue the follow-up of this study in order to address the association between early nutritional exposures and risks of cardio-metabolic dysfunction and cognitive and behavioral development later in childhood, adolescence and adulthood. Thus, we propose to follow-up these children during adolescence to assess the relationship of early life nutrition and exposures during infancy and childhood and outcomes including nutritional status, cognitive functioning, and risk for non-communicable diseases (NCDs). Findings from this study could provide awareness and information in developing policies and timely interventions to maintain optimal nutritional status throughout vulnerable life stages and reduce risks of NCDs and disabilities later in life.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy children

Exclusion criteria

  • none

Treatment and study plan

Primary outcomes

  1. Body composition

    Time frame: 1 year

    Body fat mass (kg), Body fat-free mass (kg) % body fat mass (%), % body fat-free mass (%)

Secondary outcomes

  1. Cognition

    Time frame: 1 year

    IQ scores (IQ point)

Other outcomes

  1. Cardio-vascular fitness

    Time frame: 1 year

    VO2max (L/min)

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Association of Early Life Nutritional Related Exposures and Long-term Health and Cognitive Development Outcomes in Adolescents in Northeast, Thailand

Important dates

Study start
2013
Primary completion
2018
Study completion
2018
First posted
Nov 8, 2013
Registry last updated
Jan 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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