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Completed

NCT Number: NCT06743347

Dynamic Measurement of Cerebrospinal Fluid in Healthy Subjects: Pilot Study

This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord).

The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.

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Key information

Conditions

Cerebrospinal Fluid Healthy Subjects or Volunteers

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

C.H.U. Poitiers

Poitiers, 86000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years at the time of agreement
  • Free subject, without guardianship or curatorship or subordination
  • Patients benefiting from a Social Security scheme or benefiting from it through a third party
  • Informed consent signed by the patient after clear and complete information about the study

Exclusion criteria

  • 3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc)
  • History of neurological pathology
  • Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.)
  • Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.)
  • Concurrent participation in another clinical research study
  • Persons not covered by Social Security or not covered by Social Security through a third party
  • Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection
  • Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)

Exclusion criteria

during the study:

  • Discovery of a contraindication to 3T MRI (pacemaker, cochlear implant, metallic splinter, etc)

Treatment and study plan

MRI Contrast

Other

Pass a Phase Contrast MRI. No injection required.

Primary outcomes

  1. To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)

    Time frame: Time PC-MRI will be around 60min

    Displacement velocities of CSF will be obtain by Phase Contrats MRI.

Secondary outcomes

  1. Using morphological MRI to model a digital twin

    Time frame: Time PC-MRI will be around 60min

    Comparison of velocity fields for each measurement section plane

  2. To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3)

    Time frame: Time PC-MRI will be around 60min

    Displacement velocities of blood will be obtain by Phase Contrats MRI.

Sponsors and collaborators

Lead sponsor

Poitiers University Hospital

Other

Registry information

Acronym: DYNA-LCS P

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Dec 19, 2024
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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