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NCT Number: NCT05285839

Dupixent and Narrowband UVB for Atopic Dermatitis

24 weeks open-label study with dupilumab and narrowband UVB phototherapy three times weekly for 12 weeks followed by 12 weeks of dupilumab monotherapy.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Eczema Treatment Center of New Jersey

East Windsor, New Jersey, 08520, United States

Location status: Recruiting

Location contact

Elise Nelson

CONTACT

[email protected]

609-443-4500 ext. 1402

Jerry Bagel, MD

PRINCIPAL_INVESTIGATOR

About this study

24 weeks open-label study with dupilumab and narrowband UVB phototherapy three times weekly for 12 weeks followed by 12 weeks of dupilumab monotherapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female adult ≥ 18 years of age;
  • Diagnosis of moderate to severe atopic dermatitis as defined at baseline by:
  • EASI score of 16 or greater,
  • IGA score of 3 or greater
  • BSA of 10% or greater,

Exclusion criteria

  • Subjects with previous exposure to dupilumab.
  • Known or suspected hypersensitivity to dupilumab or any of its excipients.
  • History of photosensitivity.

Treatment and study plan

Dupixent

Drug

dupilumab 300mg

Primary outcomes

  1. Investigators Global Assessment Score of score of 0 or 1

    Time frame: 12 weeks

    Proportion of subjects achieving an IGA score of 0 or 1 with at least a 2 grade improvement at week 12

Study contacts

Contact information is provided by the study sponsor or research team.

Elise Nelson

CONTACT

[email protected]

6094434500

Sponsors and collaborators

Lead sponsor

Psoriasis Treatment Center of Central New Jersey

Other

Collaborators

  • Regeneron Pharmaceuticals

Registry information

Official study title

Single Center, Pilot Study to Evaluate the Effectiveness and Safety of Dupilumab in Combination With Narrowband UVB (nUVB) Phototherapy in the Treatment of Moderate-to-Severe Atopic Dermatitis

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Mar 18, 2022
Registry last updated
Mar 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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