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NCT Number: NCT07082374

Dual Subsartorial Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty

This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA).

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Key information

Conditions

Dual Subsartorial Block Adductor Canal Block Femoral Nerve Block Postoperative Analgesia Total Knee Arthroplasty

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tanta University

Tanta, El-Gharbia, 31527, Egypt

About this study

Total knee arthroplasty (TKA) offers increased joint mobility and painless ambulation to patients. Femoral nerve block (FNB) is commonly used to relieve postoperative pain and opioid consumption.

Adductor canal block (ACB) is a common analgesic intervention for postoperative pain control following TKA. The dual subsartorial block (DSB) is a novel procedure-specific and motor-sparing regional analgesia (RA) technique that may reduce overall postoperative opioid consumption when used in conjunction with multimodal analgesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 75 years.
  • Both sexes.
  • American Society of Anesthesiology (ASA) physical status I-II.
  • Undergoing total knee arthroplasty (TKA) under general anesthesia.

Exclusion criteria

  • Severe valgus deformity.
  • Acute/chronic kidney disease.
  • Neurological deficit.
  • Cognitive dysfunction.
  • Local infection at the site of injection.
  • Coagulopathy.
  • Hypersensitivity and/or allergies to local anesthetic (LA) or any of the study medications.
  • Chronic opioid consumption (daily or almost daily use of opioids for > three months).
  • Operative limb neuropathy.

Treatment and study plan

Dual subsartorial block

Other

Patients will receive dual subsartorial block (DSB).

Adductor canal block

Other

Patients will receive an adductor canal block (ACB).

Femoral nerve block

Other

Patients will receive a femoral nerve block (FNB).

Primary outcomes

  1. Time to the 1st rescue analgesia

    Time frame: 24 hours postoperatively

    Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).

Secondary outcomes

  1. Intraoperative fentanyl consumption

    Time frame: Intraoperatively

    Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).

  2. Degree of pain

    Time frame: 24 hours postoperatively

    Each patient will be instructed about postoperative pain assessment with the visual analog scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at PACU, 2, 4, 6, 8, 12, 18 and 24 h postoperatively.

  3. Degree of patient satisfaction

    Time frame: 24 hours postoperatively

    Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied).

  4. Incidence of adverse events

    Time frame: 24 hours postoperatively

    Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, pruritus, or any other complication.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Dual Subsartorial Block Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty: A Randomized Clinical Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2025
Registry last updated
Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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