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NCT Number: NCT05476068

Dry Eye Under China's Dynamic COVID-zero Strategy

To compare the prevalence of dry eye symptoms and to investigate the association of the risk factors with the dry eye symptomatology among university students in the epidemic and non-epidemic areas of China under the COVID-zero strategy.

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Key information

Conditions

Dry Eye Symptoms Anxiety Disorders Behavior Behavioral Symptoms Depression Mental Disorders

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330000, China

About this study

As the COVID-19 outbreak at the end of 2019 spread around the world, the World Health Organization declared it a public health emergency of international concern on 30th January, and a global pandemic on 1st March. In addition to the threat of coronavirus itself, anti-epidemic measures such as wearing masks, maintaining social distance, prohibiting group gathering, blockade, isolation, curfew, closure, working at home, online learning, etc., have also greatly changed people's daily life dynamics. Unlike the previous regional blockade (city-wide) suspension of school and work, China has shifted to dynamic prevention and control in April 2020, and the basic life and activities in the epidemic area are not restricted. This study aims to compare the prevalence of dry eye symptoms and to investigate the association of the risk factors with dry eye symptoms among college students in the epidemic and non-epidemic areas of China under the dynamic COVID-zero strategy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • College students with age ≥18 years
  • No other medication history in recent 2 weeks;
  • Have high compliance and are willing to fill in the questionnaire on time

Exclusion criteria

  • routinely using artificial tears and Other eye drops;
  • taking any medication that could interfere with the results of the study;
  • with any history of eye surgery

Treatment and study plan

Primary outcomes

  1. A score of ocular surface disease index (OSDI)questionnaire

    Time frame: DAY 0

    Ocular surface disease index (OSDI)questionnaire : (1) OSDI: ≤12 (no DED symptoms), 13 ≤ d ≤ 22 (mild DED symptoms), 23 ≤ d ≤ 32 (moderate DED symptoms), and ≥33 (severe DED symptoms).

  2. A score of GAD-7 questionnaire

    Time frame: DAY 0

    GAD-7 questionnaire: (1) 0 < GAD-7 ≤ 4 (normal), 5 ≤ GAD-7 ≤ 9 (mild anxiety), 10 ≤ GAD-7 ≤ 13 (moderate anxiety), 14 ≤ GAD-7 ≤ 18 (moderate and severe anxiety), and 19 ≤ GAD-7 ≤ 21 (severe anxiety).

  3. A score of PHQ-9 questionnaire

    Time frame: DAY 0

    PHQ-9 questionnaire: (1) 0 < PHQ-9 ≤ 4 (normal), 5 ≤ GAD-7 ≤ 9 (mild depression), 10 ≤ GAD-7 ≤ 14 (moderate depression), 15 ≤ GAD-7 ≤ 19 (moderate and severe depression), and 20 ≤ GAD-7 ≤ 27 (severe depression).

Secondary outcomes

  1. A score of UCLA Loneliness Scale questionnaire

    Time frame: DAY 0

    UCLA Loneliness Scale Questionnaire: (1) UCLA < 28 (low loneliness), 28 ≤ UCLA ≤ 33 (generally lower), 33 < UCLA ≤ 39 (intermediate level), 39 < UCLA ≤ 44 (generally higher), and GAD-7 > 44 (highly lonely).

  2. Students' increased use of mobile phones

    Time frame: DAY 0

    Students choose to increase the time of using mobile phones according to options: 0 hours, less than 1 hour, 1-3 hours, 3-5 hours, 5-7 hours, and more than 7 hours

  3. Frequency of student sports

    Time frame: DAY 0

    Students choose the frequency of sports according to the options, which are: less than once a month, 2-3 times a month, 1-2 times a week, 3-5 times a week, and once a day.

Sponsors and collaborators

Lead sponsor

Yifeng Yu

Other

Registry information

Official study title

Dry Eye Symptoms of University Students Under China's Dynamic COVID-zero Strategy: A Comparison Between the Epidemic and Non-epidemic Areas

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jul 27, 2022
Registry last updated
Jul 27, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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