Comparison of Ocular Lubricants in People With Symptoms of Dry Eye

Inclusion criteria

• Are at least 18 years of age and have full legal capacity to volunteer;
• Have understood and signed an institutional review board (IRB)/ independent ethics committee (IEC) approved informed consent form;
• Are willing and able to attend all study visits as required per protocol;
• Are willing to discontinue use of all habitual artificial tear supplements and use only the study drops as directed for the entire study duration;
• Have dry eye symptomatology as per Tear Film & Ocular Surface Society Dry Eye WorkShop (TFOS DEWS) II definition:

• Have an Ocular Surface Disease Index (OSDI) score ≥13;
• Have an absence of active* anterior segment disease;
• Have not worn contact lenses for the previous 14 days before screening, and are willing to not wear contact lenses for the duration of the study;
• Are correctable to a visual acuity of +0.20 LogMAR or better (in at least one eye) with refraction results.

Exclusion criteria

• Have taken part in an interventional clinical study within the previous 14 days before screening;
• Are participating in any concurrent ocular or interventional clinical trial;
• Have any active* ocular inflammation, infection, or are using ocular topical treatment (other than dry eye drops);
• Started any systemic medication known to cause dry eye (e.g., anti-histamine, antidepressants, benzodiazepines, etc.) within 30 days before screening. Stable dosing for >30 days before screening is allowed, but changes (including commencing new) of dosing of such medication within the study period would lead to early exit from the study;
• Had any ocular injury or surgery within the 1 year prior to screening, nor have ocular surgery planned/ anticipated;
• Have biomicroscopy signs of grade 3 or more (Efron scale);
• Have known sensitivity to the diagnostic pharmaceuticals or to any ingredients in the study products;
• Are pregnant, lactating or planning a pregnancy at the time of enrolment;
• Are a member of the Centre for Ocular Research & Education directly involved in this study (on the delegation log);
• Are an employee of Alcon.