Dry Eye in Women With Turner Syndrome a… | Clinical Trial

Key information

Conditions

Turner Syndrome Adnexal Diseases Cardiovascular Abnormalities Cardiovascular Diseases Chromosome Aberrations Chromosome Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Disease Disorders of Sex Development Endocrine System Diseases Eye Abnormalities Eye Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genetic Diseases, Inborn Genital Diseases Genital Diseases, Female Gonadal Disorders Gonadal Dysgenesis Heart Defects, Congenital Heart Diseases Male Urogenital Diseases Menopause Ovarian Diseases Ovarian Failure, Premature Pathologic Processes Pathological Conditions, Signs and Symptoms Perimenopause Primary Ovarian Insufficiency Sex Chromosome Aberrations Sex Chromosome Disorders Sex Chromosome Disorders of Sex Development Urogenital Abnormalities Urogenital Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

About this study

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

Ability to understand and give informed consent.
Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age matched control for study participant with TS or POF.
For non Turner syndrome subjects only - Negative pregnancy test or post menopausal status for greater than or equal to 1 year.
Karyotype of XO for TS subjects or XX for POF and age matched control subjects.

Exclusion criteria

Persons less than 18 years old.
Persons with ophthalmic diseases associated with ocular surface disease.
Hyperprolactinemia.
Cushing s syndrome.
Other endocrine disorders which impact sex steroid hormones.
AIDS
Pregnancy or lactation.
For age matched control population ONLY- complaints of dry eye.
For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.

Sponsors and collaborators

Lead sponsor

National Eye Institute (NEI)

Nih

Registry information

Official study title

Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome

Important dates

Study start: 2007
Study completion: 2014
First posted: May 10, 2007
Registry last updated: Feb 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed