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Completed

NCT Number: NCT01931683

Dosing Study of Remifentanil for Smooth Removal of the Laryngeal Mask Airway (LMA)

The investigators attempted to determine the optimal effect-site concentration of remifentanil for smooth removal of the LMA from propofol anesthesia.

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Key information

Conditions

Drug Usage

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ajou University School of Medicine

Suwon, 443-721, South Korea

About this study

At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). LMA removal was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II patients undergoing general anesthesia for short elective surgery (<1 hr)

Exclusion criteria

  • G-E reflux
  • obesity (BMI>30)
  • anticipated difficult airway

Treatment and study plan

Remifentanil

Drug

The concentration of remifentanil was determined by modified Dixon's up-and-down method, starting from 1.0 ng/ml (0.2 ng/ml as a step size)

Other names: Ultiva

Laryngeal Mask Airway (LMA)

Device

LMA was removed when the patients opened their eyes, and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed

Primary outcomes

  1. smooth removal of LMA

    Time frame: from end of surgery to removal of LMA (participants will be followed for the emergence periods, an expected average of 15 min).

    the response of patients to the removal of LMA (classified as either 'success [smooth emergence]' or 'failure') during infusion of remifentanil.

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Official study title

Effect-site Concentration of Remifentanil for Smooth Removal of the LMA From Propofol Anesthesia

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Aug 29, 2013
Registry last updated
Oct 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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