Dopaminergic Function and Food Reward

The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.

This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Adiposity Body Weight Body Weight Changes Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss

Age range

21 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

University Clinic of Tuebingen, MEG Center

Tübingen, 72076, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

female
healthy

Exclusion criteria

fMRI contraindications
claustrophobia

Treatment and study plan

Dopamine depletion vs. Balanced aminoacid drink

Dietary Supplement

Primary outcomes

Differential brain functions in the dopaminergic reward system

Time frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink

differential brain fuctions will be measured by blood oxygen level dependent effect.

Secondary outcomes

amino acid level changes due to dopamine depletion

Time frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink

Sponsors and collaborators

Lead sponsor

University Hospital Tuebingen

Other

Registry information

Important dates

Primary completion: 2014
First posted: Jul 24, 2013
Registry last updated: May 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed