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NCT Number: NCT07368777

Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction

This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dietetics Department, School of Health Sciences, Metropolitan College

Marousi, 151 25, Greece

Location status: Recruiting

Location contact

Angeliki Kapellou, PhD

CONTACT

[email protected]

+30 21 3333 0300

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged ≥18 years
  • Body mass index (BMI) ≥25 kg/m²
  • Greek-speaking (able to read and understand Greek and provide informed consent)
  • Willing and able to participate in dietary counseling and study assessments for the duration of the study

Exclusion criteria

  • Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
  • Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
  • Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
  • Pregnancy or lactation
  • Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders

Treatment and study plan

Genotype-Based Dietary Counseling

Behavioral

This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period.

Other names: Nutrigenetic dietary counseling

Standard Dietary Counseling

Behavioral

This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.

Other names: General dietary recommendations

Primary outcomes

  1. Change in Fat Mass (%)

    Time frame: baseline to end of intervention (12 months)

    Change in whole-body fat mass percentage from baseline to end of the intervention

Secondary outcomes

  1. Change in Body Weight

    Time frame: baseline to end of intervention (12 months)

    Change in body weight from baseline to end of the intervention

  2. Change in Lipid Profile

    Time frame: baseline to end of intervention (12 months)

    Change in fasting lipid profile parameters (e.g., total cholesterol, LDL-C, HDL-C, triglycerides) from baseline to end of the intervention.

Study contacts

Contact information is provided by the study sponsor or research team.

Angeliki Kapellou, PhD

CONTACT

[email protected]

+30 6938406218

Sponsors and collaborators

Lead sponsor

Metropolitan College

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jan 27, 2026
Registry last updated
Jan 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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