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Completed

NCT Number: NCT03945708

Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery?

The study aims to investigate the effect of addition of an adsorber during cardio pulmonary bypassin patients with infective endocarditis undergoing valve surgery, and if it will decrease the use of vasoactive drugs postoperatively.

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Key information

Conditions

Infective Endocarditis Cardiovascular Diseases Endocarditis Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sahlgrenska University Hospital

Gothenburg, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infected endocarditis patients undergoing heart valve surgery.
  • Age over 18 years.

Exclusion criteria

1 Declines participation

Treatment and study plan

CytoSorb

Device

Addition of a hemofilter to the cardiopulmonary bypass circuit

Primary outcomes

  1. Use of vasoactive substances

    Time frame: 48 hours

    Use of norepinephrine in ICU

Secondary outcomes

  1. Milrinone use

    Time frame: 48 hours

    Amount of milrinone used 24 and 48 hours postoperatively

  2. Chest tube bleeding

    Time frame: 48 hours

    Chest tube output in ml

  3. Blood transfusions

    Time frame: 48 hours

    Transfusion of red blood cells, plasma and platelets

Sponsors and collaborators

Lead sponsor

Emma Hansson

Other

Collaborators

  • CytoSorbents, Inc

Registry information

Official study title

Does Whole Blood Adsorber During CPB Reduce the Amount of Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery? -a Randomized Controlled Study

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
May 10, 2019
Registry last updated
Sep 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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