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OpenTrials
Completed

NCT Number: NCT03097692

Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

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Key information

Conditions

Neutrophil Lymphocyte Ratio Inflammation Mechanical Ventilation Pathologic Processes Pathological Conditions, Signs and Symptoms Serum Createnine

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Emad Zarief Kamel Said

Asyut, 71111, Egypt

About this study

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-60 years old
  • American Society of Anesthesiologists physical status II and III
  • Patients scheduled for open heart surgery
  • no active inflammatory process

Exclusion criteria

Exclusion Criteria:

  • Emergency surgery
  • Clinically significant kidney or liver disease
  • Patients allergic to local anesthetic
  • Patients with prolonged cardiopulmonary bypass time (>120 min)
  • Patients required intra-aortic balloon pump
  • Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Treatment and study plan

Ischemic preconditioning

Procedure

ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Pharmacologic preconditionig

Drug

Pharmacologic preconditionig will be attained by sevoflurane anesthesia

Primary outcomes

  1. change of Neutrophil lymphocyte ratio

    Time frame: during first two postoperative days

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Variable Types of Preconditioning,is There a Different Impact Upon Multiorgan Function After Open Heart Surgery ?

Important dates

Study start
2016
Primary completion
2016
Study completion
2017
First posted
Mar 31, 2017
Registry last updated
Dec 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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