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Completed

NCT Number: NCT05666622

DNI Values After Periodontal Treatment

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

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Key information

Conditions

Periodontitis Inflammatory Response Mouth Diseases Periodontal Diseases Periodontal Inflammation Stomatognathic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kahramanmaraş Sütçü İmam University

Kahramanmaraş, Turkey (Türkiye)

About this study

The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal disease has not been comprehensively documented. The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with periodontitis
  • Patients have more than 20 teeth in the mouth
  • Minimum age 18
  • Maximum age 65

Exclusion criteria

  • Patients with any systemic disease
  • Active smokers
  • Pregnant or breastfeeding
  • Patients have used any antibiotic or anti-inflammatory drug in the last 6 months
  • Patients have received any periodontal treatment in the last 6 months.

Treatment and study plan

Only routine non-surgical periodontal treatment was applied to the patients.

Other

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after non-surgical periodontal treatment

Primary outcomes

  1. Changes in Delta Neutrophil Index values of periodontal treatment in patients with periodontitis.

    Time frame: 12 weeks

    We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment.

Secondary outcomes

  1. Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

    Time frame: 12 weeks

    We expect a decrease in the neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

Sponsors and collaborators

Lead sponsor

Kahramanmaras Sutcu Imam University

Other

Registry information

Official study title

Can Delta Neutrophil Index Values Predict the Success of Periodontal Treatment in Patients With Periodontitis?

Important dates

Study start
2020
Primary completion
2021
Study completion
2022
First posted
Dec 28, 2022
Registry last updated
Jan 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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