DNA Methylation and 1-C Metabolism Nutrient Intake

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays.

The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

DNA Methylation

Age range

27 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study
Completed a 121-item Food Frequency Questionnaire
Had a blood DNA sample with a measure of methylation

Exclusion criteria

Missing data in any of the outcome, exposure, or confounders (N=797 excluded)

Treatment and study plan

Primary outcomes

Blood DNA methylation

Time frame: 2014-2015

Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay

Secondary outcomes

Blood DNA methylation

Time frame: 2014-2015

Methylation of DNA from peripheral blood, LINE-1, Alu, Sat2

Sponsors and collaborators

Lead sponsor

Cancer Council Victoria

Other

Registry information

Official study title

Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Jul 24, 2017
Registry last updated: Jul 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed