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OpenTrials
Enrolling by Invitation

NCT Number: NCT07055555

Disrupted Connections: The Impact of Acute Stress on Memory Integration

The goal of this study is to better understand how stress impacts people's ability to learn across their experiences and link new information to what they already know. The investigators will compare performance on a memory task between stressed and non-stressed participants. This memory task requires people to integrate knowledge across learning experiences (think: having to "connect the dots", draw inferences, and generalize your knowledge to new situations and scenarios). Cortisol, the brain's primary stress hormone, will be measured at multiple points throughout the study to measure stress levels. The investigators hypothesize that:

1. Stress will disrupt performance on the memory task by interfering with memory processes that enable linking of related memories. 2. Higher cortisol levels, which reflect a greater stress response, will relate to greater deficits in memory performance across participants.

This research has broad implications for understanding how stress impacts the ability to learn and retain new information, particularly in high-stress environments like schools and workplaces. Additionally, this work may provide insights into the cognitive difficulties experienced by individuals with psychiatric disorders, where stress can worsen memory and learning challenges.

Enrolling by Invitation

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nevada State University

Henderson, Nevada, 89002-9776, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults
  • aged 18-35 years
  • speak fluent English
  • have normal or corrected-to-normal vision

Exclusion criteria

  • individuals who are pregnant
  • exercise within 1 hour of the study session
  • smoking within 1 hour of the study session
  • consuming drugs or alcohol within 1 hour of the study session

Treatment and study plan

Acute Stress

Behavioral

Participants randomized to the acute stress condition will complete the Trier Social Stress Test (TSST), a validated experimental method for inducing acute psychosocial stress. The TSST consists of a brief anticipation period followed by a 5-minute mock job interview and a 5-minute surprise mental arithmetic task, performed in front of a neutral panel of judges in professional attire.

Other names: Trier Social Stress Test

Non-Stress Control Task

Behavioral

Participants randomized to the control condition will complete a non-stressful task designed to parallel the structure of the Trier Social Stress Test without eliciting acute stress. They will have a brief anticipation period followed by a 5-minute description of their typical day or favorite hobby. This task is conducted without an evaluative panel, minimizing the potential for stress or anxiety.

Primary outcomes

  1. Performance on A-C inference trials in the Paired Associative Inference Task

    Time frame: During the participant's study visit, anticipated 1-2 hours

    Performance on A-C inference trials of the memory task assesses memory integration across overlapping learning experiences.

Secondary outcomes

  1. Performance on directly learned pairs (A-B and B-C) in the Paired Associative Inference Task

    Time frame: During the participant's study visit, anticipated 1-2 hours

    Performance on directly learned pairs (A-B and B-C) evaluates basic associative memory.

Sponsors and collaborators

Lead sponsor

Nevada State University

Other

Collaborators

  • National Institute of General Medical Sciences (NIGMS)
  • University of Nevada, Reno

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 9, 2025
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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