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Completed

NCT Number: NCT06626607

Different Antihypertensive Drugs on Aortic Diseases

The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is:

Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

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Key information

Conditions

Aortic Aneurysm Acute Aortic Syndrome Aneurysm Aortic Diseases Aortic Dissection Cardiovascular Diseases Dissection, Blood Vessel Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses.

This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aortic diseases' patients underwent aortic surgery who require antihypertensive medication.

Exclusion criteria

  • Patients with active vasculitis;
  • Patients allergic to contrast agent
  • Patients with aorta variation

Treatment and study plan

CCB use

Drug

Postoperative antihypertensive medication includes CCB

non-CCB use

Drug

Postoperative antihypertensive medication does not include CCB

Primary outcomes

  1. Aortic diameter

    Time frame: Through the study completion, on an average of 3 years

    The maximum diameter of the aorta measured by computed tomography angiography

Secondary outcomes

  1. Number of Participants with adverse aortic event

    Time frame: Through the study completion, on an average of 3 years

    Postoperative adverse aortic event during follow-up, including aortic related death or reoperation

Sponsors and collaborators

Lead sponsor

Eighth Affiliated Hospital, Sun Yat-sen University

Other

Collaborators

  • Beijing Anzhen Hospital

Registry information

Official study title

A Study of the Effect of Different Antihypertensive Drugs on the Disease Progression of Aortic Dissection/Aneurysm

Acronym: DADAD

Important dates

Study start
2017
Primary completion
2024
Study completion
2024
First posted
Oct 4, 2024
Registry last updated
Oct 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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