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NCT Number: NCT04689139

Biomarkers in Thoracic Aorta Surgery

Biomarkers can play a vital role in prognosing the perioperative complications in thoracic aorta surgery. The goal of a study is to determine the correlation between intraoperative level of certain biomarkers and total amount of peroperative complications.

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Key information

Conditions

Aortic Aneurysm Acute Aortic Syndrome Aneurysm Aortic Diseases Aortic Dissection Cardiovascular Diseases Complication Dissection, Blood Vessel Thoracoabdominal Aneurysm Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Petrovsky Research National Centre of Surgery ( Petrovsky NRCS)

Moscow, 119991, Russia

About this study

This study aims to assess the association between levels of biomarkers and postoperative complications in patients after thoracic and thoracoabdominal aortic reconstruction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective thoracic and thoracoabdominal surgery

Exclusion criteria

  • Hemolysis in blood sample

Treatment and study plan

blood sample tests for determination of biomarkers levels

Diagnostic Test

Using of proadrenomedullin, presepsin, NT-proBNP, Troponin I to determine the correlation of perioperative complications.

Primary outcomes

  1. Number of Total Postoperative Complications

    Time frame: up to 10 days

    Value reported in the Outcome Measure data table reflects the Number of Total Postoperative Complications across all participants.

Secondary outcomes

  1. Total Number Affected by All-Cause Mortality

    Time frame: up to 10 days

    Overall number of participants, in each arm/group, who died due to any cause

  2. Number of Participants Who Require Extracorporeal Detoxication

    Time frame: up to 10 days

  3. Number of Cardiac Disorders

    Time frame: up to 10 days

    Number of patients who needed medicamental cardiotonic support more than 1 day

  4. Number of Vascular Disorders

    Time frame: up to 10 days

    Number of patients who needed vasopressor support more than 1 day

  5. Number of Infections and Infestations

    Time frame: up to 10 days

    Number of patients who develop systemic infection and/or operation wound infection

Sponsors and collaborators

Lead sponsor

Petrovsky National Research Centre of Surgery

Other

Registry information

Official study title

Role of Intraoperative Biomarkers in Prognosis of Perioperative Complications in Reconstructive Thoracic Aorta Surgery

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Dec 30, 2020
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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