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OpenTrials
Completed

NCT Number: NCT05186636

Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans

Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.

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Key information

Conditions

Acute Renal Injury Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Alberta Children's Hospital, Calgary, Alberta, Canada

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About this study

Providing acute dialysis to critically ill patients in ICU settings is resource and cost intensive. The daily costs of acute dialysis can range from $528/day for intermittent hemodialysis to $865/day for continuous renal replacement therapy. Providing acute dialysis in ICU settings requires a specialized team of nurses, educators, physicians and stakeholders to ensure its safe and effective prescription and delivery. Acute dialysis is typically delivered to some of the most acutely ill patients admitted to the ICU to support organ function and sustain life.

At present, there is not a standardized approach to the prescription and delivery of acute dialysis therapy in ICUs across Alberta. The DIALYZING WISELY program will implement a standardized approach to the delivery of best practices for acute dialysis therapy to all patients who receive treatment across ICUs in Alberta.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient in one of 15 adult and 3 pediatric intensive care units in Alberta Receive acute RRT as part of their usual clinical care during the intervention period

Exclusion criteria

  • none

Treatment and study plan

KPI reports

Other

Quarterly

Other names: Monitoring, reporting and regular review of acute RRT KPIs

Prescriber reports

Other

Individualized prescriber reports for acute RRT initiation patterns along with targeted education to ensure that align with best evidence-based practices

Primary outcomes

  1. Key performance indicators (KPI)

    Time frame: Throughout intervention period up to 3 years

    Changes in acute KPIs

  2. Health system costs

    Time frame: 3 years

    Acute RRT and healthcare systems costs

Secondary outcomes

  1. Length of renal replacement therapy

    Time frame: 3 years

    Length of time patient receives RRT during their ICU stay

  2. ICU and hospital lengths of stay

    Time frame: 3 years

    Number of days patient spends in the ICU and hospital

  3. ICU and 90 day mortality

    Time frame: 3 years

    number of patients who die before ICU discharge or within 90 days of ICU stay

  4. Rates of RRT dependence at 90 days

    Time frame: 3 years

    number of patients who are receiving RRT at 90 days after ICU stay

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Collaborators

  • Alberta Innovates Health Solutions

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jan 11, 2022
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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