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Completed

NCT Number: NCT01852539

Dexmedetomidine for Laryngeal Mask Airway Insertion

The investigators attempted to determine the optimal dose of dexmedetomidine required for the successful insertion of LMA during propofol induction without a neuromuscular blocking agent.

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Key information

Conditions

Drug Usage

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ajou University School of Medicine

Suwon, 443-721, South Korea

About this study

After a predetermined bolus dose of dexmedetomidine was injected over 2 min, anesthesia was induced with propofol 2.0 mg/kg. After confirming the loss of eyelash reflex and the bispectral index (BIS) score decreased below 60, the insertion of LMA was attempted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II patients undergoing general anesthesia for short elective surgery (<1 hr)

Exclusion criteria

  • G-E reflux
  • obesity (BMI>30)
  • anticipated difficult airway

Treatment and study plan

Dexmedetomidine

Drug

The dose of dexmedetomidine was determined by modified Dixon's up-and-down method, starting from 0.5 μg/kg (0.1 μg/kg as a step size).

Other names: precedex

Propofol

Drug

Propofol 2.0 mg/kg was administrated

Other names: 2% fresofol

Laryngeal Mask Airway (LMA)

Device

The insertion of laryngeal mask airway (LMA) was attempted, after confirming the loss of eyelash reflex,the bispectral index (BIS) score decreased below 60.

Primary outcomes

  1. successful insertion of LMA

    Time frame: from baseline to 2 min after insertion of LMA (participants will be followed for the duration of anesthetic induction, an expected average of 10 min).

    the response of patients to the insertion of LMA (classified as either 'movement' or 'no movement') during infusion of dexmedetomidine and propofol.

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Official study title

Optimal Dose of Dexmedetomidine for Laryngeal Mask Airway Insertion During Propofol Induction

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
May 13, 2013
Registry last updated
Apr 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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