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Completed

NCT Number: NCT07058493

Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgery

Dexmedetomidine used as an Additive for Ipack Block in Knee Surgery

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Key information

Conditions

Knee Surgeries

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine Cairo university

Cairo, Egypt

About this study

Many types of analgesia used but multimodal analgesia showed best results The interspace between the popliteal artery and capsule of the posterior knee (IPACK) block aims to blockade of sciatic nerve terminal branches for analgesia without motor affection

. (IPACK) block is a motor power sparing procedure that involves injecting local anesthetic into the space between the popliteal artery and the posterior capsule of the knee in order to treat posterior knee pain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-60 years
  • ASA I, II .patients undergoing knee surgeries.

Exclusion criteria

  • patient Refusal
  • bleeding disorders
  • skin lesion
  • infection
  • known allergy
  • contradictions of spinal anesthesia

Treatment and study plan

Dexmedetomidine

Drug

dexmedetomidine 100 μg as adjuvant to IPACK block with 20 ml of bupivacaine 0.25%.

Bupivacaine

Drug

20 ml of bupivacaine 0.25%.

Primary outcomes

  1. Visual Analog Scale at rest score during first postoperative 48 hours

    Time frame: 48 postoperative hours

    Visual Analog Scale at rest during first postoperative 48 hours a line 10centimeters long from zero to10 where 10 is the worst pain ever

Secondary outcomes

  1. Visual Analog Scale at rest and during movement at 30 minuts, 2, 8, 16, 24, 36, and 48 hours

    Time frame: 48 postoperative hours

    Visual Analog Scale at rest during 48 postoperative hour a line 10centimeters long from zero to10 where 10 is the worst pain ever

  2. Duration of the block

    Time frame: 48 hours

    Duration of the block

  3. Heart Rate

    Time frame: 48 hours

    Heart Rate

  4. Mean Arterial Pressure

    Time frame: 48 hours

    Mean Arterial Pressure

  5. Block performance time in minutes

    Time frame: preoperative

    Block performance time in minutes

  6. Incidence of adverse effects

    Time frame: 2 hours inPACU

    Incidence of adverse effects

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Analgesic Effect of Using Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgeries in Adult Patient; A Randomized Controlled Trial

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 10, 2025
Registry last updated
Jul 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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