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NCT Number: NCT06809842

Analgesic Efficacy of Blocking Nerve to Vastus Lateralis Muscle Versus Lateral Femoral Cutaneous Nerve After Knee Surgeries

This study aims to compare the analgesic efficacy and functional outcomes of blocking the nerve to the vastus lateralis (NVL) muscle versus the lateral femoral cutaneous nerve (LFCN).

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Key information

Conditions

Analgesia Agnosia Knee Surgeries Lateral Femoral Cutaneous Nerve Block Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms Vastus Lateralis Nerve Block

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, 33516, Egypt

Location status: Recruiting

Location contact

Sherif K Arafa, MD

CONTACT

[email protected]

00201005714014

About this study

Knee surgeries are associated with significant postoperative pain, which can impede early mobilization and prolong recovery. Recent advancements in ultrasound-guided regional anesthesia have enabled more targeted nerve blocks, such as the blockade of the nerve to the vastus lateralis (NVL) and the lateral femoral cutaneous nerve (LFCN)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years.
  • Both sexes.
  • American Society of Anesthesiologists (ASA) physical status from I to III.
  • Underwent knee surgeries under spinal anesthesia.

Exclusion criteria

  • Pregnancy.
  • Coagulopathy.
  • Neuromuscular disorders.
  • Hematological disorders.
  • Mental disorders.
  • History of multiple traumas or anesthesia drug allergies.
  • Local skin infection at the block site.
  • Body mass index (BMI) greater than 40.
  • Opioid analgesics or abusing opioids.

Treatment and study plan

Vastus lateralis nerve block

Drug

Patients received vastus lateralis nerve block with 5 ml of bupivacaine 0.5%.

Other names: Bupivacaine 0.5%

Lateral femoral cutaneous nerve block

Drug

Patients received lateral femoral cutaneous nerve block with 5 ml of bupivacaine 0.5%.

Other names: Bupivacaine 0.5%

Primary outcomes

  1. Degree of pain

    Time frame: 24 hours postoperatively

    Each patient will be instructed about postoperative pain assessment using the numeric rating scale (NRS) score (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS assessments will be conducted at the post-anesthesia care unit (PACU) and at 2, 4, 6, 12, 18, and 24 hours postoperatively.

Secondary outcomes

  1. Time to first request for analgesia

    Time frame: 24 hours postoperatively

    The time to first request for analgesia will be recorded from the end of surgery till the first dose of morphine is administered.

  2. Total morphine consumption

    Time frame: 24 hours postoperatively

    If the numeric rating scale (NRS) exceeded 3, rescue analgesia in the form of a 3 mg morphine bolus will be administered, to be repeated after 30 minutes if the pain persisted until the NRS dropped below 4.

  3. Block performance time

    Time frame: Intraoperatively

    The block performance time will be recorded from the placement of the ultrasound probe to the removal of the needle after the injection of local anaesthetic.

  4. Degree of patient satisfaction

    Time frame: 24 hours postoperatively

    The degree of patient satisfaction will be measured using a 5-point Likert scale (1 = extremely dissatisfied, 2 = unsatisfied, 3 = neutral, 4 = satisfied, 5 = extremely satisfied).

  5. Length of hospital stay

    Time frame: Till the discharge from hospital (Up to one week).

    Length of hospital stay will be recorded from admission till discharge from the hospital.

  6. Incidence of adverse events

    Time frame: 24 hours postoperatively

    Incidence of adverse events such as postoperative nausea and vomiting (PONV), respiratory depression, and local anesthetic (LA) toxicity will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Sherif K Arafa, MD

CONTACT

[email protected]

00201005714014

Sponsors and collaborators

Lead sponsor

Kafrelsheikh University

Other

Registry information

Official study title

Analgesic Efficacy of Blocking Nerve to Vastus Lateralis Muscle Versus Lateral Femoral Cutaneous Nerve After Knee Surgeries: A Randomized Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 5, 2025
Registry last updated
Feb 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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