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OpenTrials
Completed

NCT Number: NCT01142037

Development of a Biomarker for Dietary Furanocoumarins

Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.

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Key information

Conditions

Cancer Healthy Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Food Science and Nutrition, University of Minnesota

Saint Paul, Minnesota, 55108, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must be at least 18 years of age
  • Healthy

Exclusion criteria

  • History of gastrointestinal, hepatic or renal disorder
  • Currently taking any prescription or over-the-counter medication
  • Currently taking any herbal supplement
  • Pregnant or lactating
  • Allergies to foods that will be used (parsnips and parsley)

Treatment and study plan

Cooked parsnips with parsley

Dietary Supplement

Beginning on Day 9 participants will be given cooked parsnips with parsley at a dose of 2 grams total apiaceous vegetable/kilogram body weight for period 1, and 4 gram/kilogram body weight for period 2.

Primary outcomes

  1. Urinary Biomarker Results for Dietary Furanocoumarins

    Time frame: Week 1

    determine the optimal conditions for furanocoumarin identification and quantification in human urine

Secondary outcomes

  1. Mean Concentration of Dietary Furanocoumarin in Urine

    Time frame: Week 1, 2 and 3

    Determine dose response of dietary furanocoumarin in urine - Comparison of Pre-Dose, Low-Dose and High Dose diet of furanocoumarin in subjects' urine collected (ng/ml).

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Jun 11, 2010
Registry last updated
Aug 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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