Ezra Faster Scan Study

The Ezra Faster Scan study uses non-invasive magnetic resonance imaging (MRI) technology that can "visually" detect early and late-stage cancer, and other pathologies. MRIs use a magnetic field and radio waves to create a 3-dimensional (3D) image of an individual's body without using ionizing radiation.

The purpose of this research is to decrease the amount of time required by an individual to complete an early cancer screening comprehensive magnetic resonance imaging (MRI) scan, such as the Ezra Full Body MRI imaging scan. If the time required to conduct a comprehensive scan is reduced, the cost of the scan may also decrease. By decreasing consumer costs and time, more individuals may be able to afford MRI-based early cancer screening technology.

Participants in this study will undergo a minimum 30-minute MRI session. These sessions will be used to evaluate new MRI "instructions" that allow for a faster MRI scan time. The images will also be used to develop mathematical models or machine learning tools that allow images to be enhanced. By enhancing images using machine learning, they may be restored to a quality typically observed in MRI sessions with longer scan (acquisition) times.

To read more about the study, potential participants may review the informed consent form located below in the References section. Potential participants may email [email protected], or call 516.340.1221.

See study Eligibility Criteria below.

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Key information

Conditions

Medical Oncology Cancer Healthy Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Various Locations, Beverly Hills, California, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ability to provide legal informed consent and 18 years of age or older
Resident of the contiguous United States and located within proximity of a designated research MRI facility
Ability to travel to designated research MRI facilities

Exclusion criteria

Unable to receive an MRI due to existing implanted medical devices that may be disrupted by magnetic field or metal components/fragments that may migrate due to magnetic fields (pacemaker or defibrillator, stimulators, or stimulator wires (pacing leads), non-removeable metal dentures/braces/wires, surgical clips, (drug) pumps. Note metallic dental crowns or fillings are permitted.
Those with orbital (eye socket) trauma caused by a metallic object
Those with metallic fragments within the eye (foundry workers)
Those with implanted cardiac pacemakers, implantable cardioverter defibrillators (ICDs), or diaphragmatic pacemakers, cardiac resynchronization therapy devices, implantable cardiovascular monitors, implantable loop recorders, neurostimulators
Those with intra-cranial vascular clips (aneurysm), or prosthetic heart valve
Those with shrapnel form a prior accident
Those with a LINX Reflux Management System to control gastro esophageal reflux disease (GERD)
Those with non-removable insulin pumps or other drug pumps
Those with cochlear implants
Those with breast (inflatable breast tissue implants) or other tissue expanders (cosmetic or other implant)
Those with tubal ligation clips or non-removable intrauterine device (IUD)
Those with Sensimed Triggerfish ocular monitoring systems (glaucoma)
Those receiving ambulatory care
Employee of Ezra Health of California, P.C., Ezra AI Incorporated or Ezra AI Canada Incorporated
Mental health disability, cognitive disability, neurological or other existing condition that may impact ability to provide informed consent
Those that recently experienced a stroke that may impair judgement
Those that have some difficulty or higher, remembering, concentrating, communicating, or being understood (sponsor reviewed)
Individuals who otherwise may require a legally authorized individual (LAR) to provide consent on their behalf
Those who do not have access to the internet through a mobile device or computer
Those who are pregnant at the time of informed consent or prior to a scheduled MRI appointment
Those who are incarcerated or on probation
Those who may not have reading proficiency of study supported document languages (questionnaires, consent forms, or third-party oral translation services)
Those who cannot read due to visual impairment and cannot provide an impartial witness to support informed consent or study survey questionnaires
Those with a hearing impairment and cannot provide an impartial witness to support informed consent

Treatment and study plan

Magnetic Resonance Imaging

Other

Participants are required to undergo a non-invasive magnetic resonance imaging (MRI) scan approximately 30 minutes in length.

Other names: MRI

Primary outcomes

Accelerated MRI Sequence Protocol Time (s)

Time frame: Approximately 30 minutes for each participant scan . Additional computational analysis of images throughout the study duration.

The MRI scan time (minutes, seconds) for MRI instructions or sequences to be completed and qualitative feedback from MRI technologists and radiologists on execution of instrument instructions.
Statistical Analysis of MRI Images (Accelerated)

Time frame: Approximately 30 minutes for each participant scan. Additional computational analysis of images throughout the study duration.

Computed image signal-to-noise and contrast-to-noise ratios of machine learning-restored accelerated images relative to accelerated images.
Statistical Analysis of MRI Images (Reference)

Time frame: Approximately 30 minutes for each participant scan. Additional computational analysis of images throughout the study duration.

Computed image signal-to-noise and contrast-to-noise ratios of machine learning-restored accelerated images relative to reference images.
Statistical Analysis of MRI Images (Likert)

Time frame: Approximately 10 minutes of a radiologist's time. Additional analysis of images throughout the study duration.

Visual radiologist review of reference and machine learning restored images. Images are reviewed using a Likert scale, comparing a reference image to a machine learning restored image. The scale grades are a radiologist's objective opinion of whether a machine learning restored image is similar to a reference image. If the machine learning image is worse, the radiologist rates the image strongly disagree or -2, if the machine learning image is better than the reference image, the radiologist selects strongly agree or 2. The Likert scale extends from worse to improved in the following order; strongly disagree (worse) -2, disagree -1, neither agree or disagree (neutral) 0, agree 1, or strongly agree 2. The minimum value is -2 and the maximum value is 2. A higher score greater than 0 indicates a better image, a lower score less than 0 indicates a worse image or outcome.

Sponsors and collaborators

Lead sponsor

Ezra AI, Inc.

Industry

Registry information

Acronym: FasterScan

Important dates

Study start: 2022
Primary completion: 2025
Study completion: 2025
First posted: May 23, 2022
Registry last updated: Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed