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NCT Number: NCT05476523

Development and Validation of a Novel Eye-Tracking Software-based Platform to Extract Oculometric Measures

This is an observational prospective study in a cohort of healthy subjects who are enrolled using convenience and snowballing sampling. The aims of the study is to demonstrate the efficacy of using NeuraLight system to capture oculometric data from healthy participants and to validate the data capture of NeuraLight oculometric measurements as compared with a validated eye-tracker system in subjects who meet the inclusion criteria and who provide a signed Informed Consent.

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Key information

Conditions

Eye Movement

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

NeuraLight

Wilmington, Delaware, 19801, United States

Location status: Recruiting

Location contact

Eitan Raveh, PhD

CONTACT

About this study

The purpose of the trial is to demonstrate the efficacy of using NeuraLight system to capture oculometric data from healthy participants, and to validate the data capture of NeuraLight oculometric measurements as compared with a validated eye-tracker system. In addition, we also aim to collect oculometric data from healthy participants in order to optimize a regression model which can be used for future prediction of clinical endpoints in various neurological patients at different stages of disease

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women ages between 18 and 90 years old
  • Normal or corrected vision
  • Ability to follow instructions
  • Willing and able to sign an informed consent form

Exclusion criteria

  • Inability to sit for 20 minutes on a chair in a calm manner
  • Personal or 1st degree relative history of epilepsy
  • Additional neurological diseases
  • Drug or alcohol abuse

Treatment and study plan

NeuraLight

Other

NeuraLight is an investigational software-based platform used for measuring eye movements in response to visual stimuli and captured using a simple webcam

Primary outcomes

  1. Efficacy of data capture

    Time frame: 36 months

    Capturing >50 different oculometric measures in >95% of a cohort of up to 2000 subjects

  2. Validation of data capture

    Time frame: 36 months

    Relative root mean square error (RMSE) of NeuraLight's extracted oculometric measures compared with retrieved measurements from a validated eye tracking system <0.1

Secondary outcomes

  1. Optimization of data capture

    Time frame: 36 months

    Optimization of a feature selection model (Fisher's Linear Discriminant Analysis (LDA)) on NeuraLight oculometric measures used for a logistic regression model of clinical endpoints with a relative root mean square error (RMSE) of <0.1

Study contacts

Contact information is provided by the study sponsor or research team.

Eitan Raveh, PhD

CONTACT

[email protected]

+972-58-6277947

Sponsors and collaborators

Lead sponsor

NeuraLight

Industry

Registry information

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Jul 27, 2022
Registry last updated
May 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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