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NCT Number: NCT07622303

Depression, Anxiety and Sleep in Parkinson's Disease

This study aims to assess the prevalence and severity of depression, anxiety, and sleep disorders among patients with idiopathic Parkinson's disease. The study will evaluate the relationship between neuropsychiatric symptoms and disease characteristics in order to improve early recognition and patient quality of life.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

A-Inclusion Criteria:

  • Patients diagnosed with idiopathic Parkinson's disease according to the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease (Postuma et al., 2015).
  • Age ≥ 50 years.
  • Ability to understand and respond to questionnaires and rating scales.
  • Ability and willingness to provide informed consent.

B-Exclusion Criteria:

  • Patients with atypical parkinsonism.
  • Patients with a history of other major neurological disorders (e.g., stroke, Alzheimer's disease, multiple sclerosis).
  • Patients with severe cognitive impairment or dementia that prevents reliable completion of rating scales.
  • Patients with a current diagnosis of severe psychiatric disorders unrelated to 5-Parkinson's disease (e.g., schizophrenia, bipolar disorder).

6-Patients with unstable medical conditions. 7-Patients unable or unwilling to provide informed consent.

Treatment and study plan

Primary outcomes

  1. Assessment of Depression Severity in Patients with idiopathic Parkinson's Disease

    Time frame: Baseline assessment during study enrollment.

    Depression severity measured using the Hamilton Depression Rating Scale (HAM-D). Scores range from 0 to 52, with higher scores indicating more severe depression.

  2. Assessment of Anxiety Severity in Patients with idiopathic Parkinson's Disease

    Time frame: Baseline

    Anxiety severity measured using the Hamilton Anxiety Rating Scale (HAM-A). Scores range from 0 to 56, with higher scores indicating more severe anxiety.

  3. Assessment of Sleep Disturbance in Patients with idiopathic Parkinson's Disease

    Time frame: Baseline

    Sleep disturbance measured using the Parkinson's Disease Sleep Scale (PDSS). Higher scores indicate better sleep quality and fewer sleep-related symptoms.

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Assessment of Depression , Anxiety and Sleep Disorders in Patients With Idiopathic Parkinson's Disease

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 3, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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