DEPLIPIDO Study: Functional and Lipidomic Analysis of Plasma HDL in Patients With Depression Compared to Controls

Inclusion criteria

• FOR PATIENTS WITH RECURRENT DEPRESSION :

• Patient who has provided oral consent
• Adult with moderate to severe depression according to DSM-5 criteria (Hamilton HDRS-17 score ≥ 18), with a number of depressive episodes ≥ 3
• PATIENTS PRESENTING WITH A FIRST DEPRESSIVE EPISODE

• Patient who has provided oral consent
• Adult with moderate to severe characterized depression according to DSM-5 criteria (Hamilton HDRS-17 scale score ≥ 18) presenting with a first depressive episode.
• CONTROLS

• Person who has provided oral consent
• Adult who has never shown signs of depression

Exclusion criteria

• Person not affiliated with national health insurance
• Person subject to a measure of legal protection (curatorship, guardianship)
• Pregnant or breastfeeding women
• Adult unable to express consent
• Minors
• Person with a metabolic syndrome (according to NCEP/ATP-III criteria: 3 of the following 5 criteria: Waist circumference ≥ 102 cm in males and ≥ 88cm in females, Triglycerides > 1.50 g/L, HDL-Cholesterol < 0.40 g/L in H, HDL-Cholesterol < 0.50 g/L in F, Blood pressure ≥130/85mmHg, Fasting blood glucose ≥ 1.10 g/L),
• Person with type 1 or type 2 diabetes,
• Person with a mild depressive episode (HDRS-17<18),
• Person with concomitant antipsychotic treatment
• Person with bipolar disorder,
• Person with a moderate to severe alcohol use disorder according to DSM-5 criteria
• Person with schizophrenia,
• Person with a persistent delusional disorder,
• Person with an autism spectrum disorder.