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NCT Number: NCT06457373

Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation

This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.

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Key information

Conditions

Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

25 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry- Horus University in Egypt

Damietta, New-Damietta, 34518, Egypt

Location contact

Mohamed Habib, B.D.S

CONTACT

[email protected]

+2001069505336

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged between 25 to 35 years old.
  • Patients scored as (ASA I).
  • No adverse habits such as smoking, tobacco chewing, alcohol.
  • Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).
  • The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.
  • Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.
  • Patients sign a consent for all procedures.

Exclusion criteria

  • 1) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.

Treatment and study plan

Demineralized Dentin Allograft

Procedure

20 sockets are randomly allocated to receive the Demineralized Dentin Allograft (split-mouth study)

Other names: DDA

Demineralized Dentin Autograft

Procedure

20 sockets are randomly allocated to receive the Demineralized Dentin Autograft (split-mouth study)

Other names: Auto-DD

Primary outcomes

  1. Measuring and comparing the height of bone between the two groups

    Time frame: Immediately post-operative, 3months post-operative, 6months post-operative

    We will measure the height of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation

  2. Measuring and comparing the width of bone between the two groups

    Time frame: Immediately post-operative, 3months post-operative, 6months post-operative

    We will measure the width of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation

Secondary outcomes

  1. Assess and comparing the mouth opening of both groups

    Time frame: One day post-operative, one week post-operative

    Assess the mouth opening of the patient using a millimeter ruler (by measuring the distance between maxillary incisal edge and mandibular incisal edge) and comparing the results of both groups

  2. Assess and comparing the swelling of both groups

    Time frame: One day post-operative, one week post-operative

    Swelling levels after surgery will be measured using anatomic landmarks (Tragus-Labial commissure and Tragus-Pogonion), the distances between the landmarks used for the evaluation methods will be measured before the operation.

    All measurements will be done using millimeter ruler, while the patient will be seated.

  3. Assess and comparing the pain of both groups

    Time frame: One day post-operative, one week post-operative

    we will use the Visual Analogue Scale (VAS) for pain measurement

  4. Assess and comparing the soft tissue parameters (bleeding on probing and color of the gingiva) of both groups

    Time frame: One day post-operative, one week post-operative

    The bleeding on probing will be assessed by using periodontal probe and this will be done around mandibular first and second molars

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Khalil, PHD

CONTACT

[email protected]

+2001005062045

Mohamed Habib, B.D.S

CONTACT

[email protected]

+2001069505336

Sponsors and collaborators

Lead sponsor

Horus University

Other

Registry information

Official study title

The Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation After Surgical Extraction of Impacted Mandibular Third Molar

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 13, 2024
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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