Deep Sedation With Pre-emptive Endotracheal Intubation for Advanced Bronchoscopy Procedures

Bronchoscopy is a crucial procedure for diagnosing and treating respiratory diseases. It is recommended to be performed under sedation whenever possible, with sedation levels ranging from minimal to moderate and deep sedation. Deep sedation enhances patient comfort and facilitates the procedure, making it particularly useful for lengthy or complex bronchoscopic examinations. Additionally, deep sedation reduces involuntary patient movements and coughing, allowing the proceduralist to perform bronchoscopy more effectively when the patient is deeply sedated.

Despite its benefits, deep sedation carries the risk of respiratory depression and impaired airway maintenance, which may necessitate early termination of the bronchoscopy. If respiratory suppression or inadequate airway maintenance occurs during deep sedation, the procedure may need to be interrupted for endotracheal intubation using the bronchoscope. However, even with appropriate monitoring during bronchoscopy, determining the optimal timing for endotracheal intubation can be challenging, potentially disrupting procedural continuity and reducing the likelihood of a successful examination.

To enhance patient comfort and procedural safety, the investigator has been performing bronchoscopy under deep sedation with preemptive endotracheal intubation for several years. This clinical experience has been shared with other university hospitals in the region, and cases of deep sedation with preemptive intubation under the supervision of bronchoscopists have been reported. This study aims to evaluate the safety and feasibility of deep sedation with preemptive endotracheal intubation during bronchoscopy through a multicenter prospective observational approach.

Inclusion criteria

• Patients requiring a bronchoscopy-assisted procedure for diagnostic or therapeutic purposes
• Individuals who voluntarily consent to participate in the clinical study and sign a written informed consent form

Exclusion criteria

• Patients who have experienced acute myocardial infarction or acute stroke within the past six weeks
• Patients with contraindications to bronchoscopy (e.g., severe respiratory or cardiovascular comorbidities)
• Patients with a history of allergy to benzodiazepines, propofol, fentanyl, or flumazenil
• Patients with genetic disorders such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
• Patients with a severe hypersensitivity reaction to dextran 40
• Patients with a history of acute angle-closure glaucoma
• Pregnant women
• Prisoners
• Patients with psychiatric disorders
• Patients classified as ASA Physical Status IV or V by the American Society of Anesthesiologists (ASA)
• Any other patients deemed unsuitable for the clinical study by the investigator