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NCT Number: NCT06925373

Housing, Environment, And Living Conditions for Transformed Health

This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach.

STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease.

STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.

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Key information

Conditions

Lung Diseases Chronic Disease Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UAB Lung Health Center

Birmingham, Alabama, 35233, United States

Location status: Recruiting

Location contact

Sonya Hardy, Clinical Research Regulatory Coordinator, MA

CONTACT

[email protected]

2059346685

About this study

Participants will complete surveys, physical exam, lung function tests, and blood draw. An indoor air purifier with a usage tracker and an indoor air quality monitor will be provided, and used filters will be analyzed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults age 18 years and older
  • English speaking
  • Residents of one of 4 public housing site in Birmingham, Alabama

Exclusion criteria

  • Individuals who are not 18 years or older
  • Do not speak English
  • Do not meet the residency criteria

Treatment and study plan

Indoor Air Purification

Other

An indoor air purifier with a dual HEPA/activated carbon filter, a usage tracker, and an indoor air quality monitor will be installed in public housing residences.

Other names: Coway Airmega 400

Neighborhood Improvements

Other

Improved built environment (green space, sidewalks, street lights) and social environment (educational and workforce development programs, wrap-around social services, Internet access).

Housing Improvements

Other

High-quality public housing

Primary outcomes

  1. Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health

    Time frame: Baseline, 12 months, 24 months

    A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.

  2. Change in Allostatic load

    Time frame: Baseline, 12 months

    Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin <3.8 g/dL, (2) C Reactive Protein (CRP) >3 mg/L, (3) High-Density Lipoprotein (HDL) <40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference >88 cm in women, >102 cm in men.

  3. Change in Indoor Air Quality

    Time frame: Baseline, 6 months, 12 months (Study 2 only)

    Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.

Secondary outcomes

  1. The percentage change in FEV1/FVC

    Time frame: Baseline, 6 months, 12 months (Study 2 only)

    FEV1/FVC. A measure of lung funtion that compares the amount of air exhaled in the first second (FEV1) to the total amount of air exhaled in a forced breath (FVC).

Study contacts

Contact information is provided by the study sponsor or research team.

Gabriela R Oates, PhD

CONTACT

[email protected]

205-996-5689

Joy R Ledvina, Program Director, MBA

CONTACT

[email protected]

205-975-7852

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

  • National Institute of Nursing Research (NINR)

Registry information

Official study title

Housing, Environment, And Living Conditions for Transformed Health (HEALTHe Birmingham)

Acronym: HEALTHe

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Apr 13, 2025
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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