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OpenTrials
Completed

NCT Number: NCT01021046

Deep Anterior Lamellar Keratoplasty (DALK) Using Acellular Corneal Tissue Promotes Corneal Allograft Survival in High Risk Patients

The purpose of this study is to study whether deep anterior lamellar keratoplasty (DALK) using acellular tissue will promote corneal graft survival in high risk patients.

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Key information

Conditions

Glycerin Cryopreserved Acellular Corneal Tissue Behavior Deep Anterior Lamellar Keratoplasty High Risk Keratoplasty Rejection, Psychology Social Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Eye Hospital, Wenzhou Medical College

Wenzhou, Zhejiang, 325027, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • severe bacterial keratitis
  • Herpes simplex keratitis
  • severe fungal keratitis
  • partial limbal deficiency after chemical burn

Exclusion criteria

  • posterior stroma involved in severe bacterial and fungal keratitis
  • dry eye
  • glaucoma or intraocular pressure greater than 21 mmHg
  • amblyopia
  • retinal abnormalities
  • patients with severe systemic diseases not good for ocular surgery

Treatment and study plan

DALK using GCCT

Procedure

Deep anterior lamellar keratoplasty (DALK) using glycerin-cryopreserved corneal tissue

Other names: acellular tissue

DALK using FCT

Procedure

Deep anterior lamellar keratoplasty (DALK) using fresh corneal tissue

Primary outcomes

  1. rejection

Secondary outcomes

  1. laser scanning in vivo confocal microscopy

Sponsors and collaborators

Lead sponsor

Wenzhou Medical University

Other

Registry information

Official study title

Deep Anterior Lamellar Keratoplasty Using Acellular Corneal Tissue Promotes Corneal Allograft Survival in High Risk Patients

Important dates

Study start
2006
Primary completion
2010
Study completion
2010
First posted
Nov 26, 2009
Registry last updated
Aug 3, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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