Daily Protein Intake Distribution and MPS (ARCIII)

To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis

Completed

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Key information

Conditions

Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Overweight/obese (BMI 27-40 kg/m2)
Non-smokers
Non-diabetic
No history of hyperlipidemia
Not taking medications thought to interfere with study
Considered generally healthy

Exclusion criteria

Efforts to lose weight in previous 16 weeks
Hyperlipidemia
Blood pressure ≥ 140/90 mmHg
Smoking
Heart and other organ disease
Type 2 diabetes
Gastrointestinal disease
Orthopedic injury interfering with exercise
Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)

Treatment and study plan

Whey Protein

Other

whey protein.

Placebo

Other

placebo.

Primary outcomes

muscle protein synthesis

Time frame: up to 4 weeks

protein synthesis is evaluated in muscle biopsy tissue

Secondary outcomes

body composition is evaluated using DEXA

Time frame: up to 4 weeks

Sponsors and collaborators

Lead sponsor

Société des Produits Nestlé (SPN)

Industry

Registry information

Official study title

Effect of Balanced Daily Protein Distribution Supplemented With Whey Protein on Muscle Protein Synthesis in Overweight Older Men During Calorie Restriction and Exercise (ARC III)

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2014
First posted: Dec 11, 2014
Registry last updated: Dec 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed