Lillehammer University College
Lillehammer, 2618, Norway
NCT Number: NCT02536066
The postprandial blood glucose concentration is an important risk factor for development of cardiovascular diseases and diabetes. Previous studies have shown that one bout of moderate or light post-meal physical activity effectively blunts the postprandial increase in blood glucose after carbohydrate intake. Pre-meal exercise does not generate such effect. Thus, the effect of exercise on postprandial glycemia depend on the timing of exercise. Even very light physical activity decreases postprandial glycemia when performed in the postprandial period. The purpose of this study was to investigate whether such activity performed each day for 12 weeks would influence blood variables related to glycemic control.
METHODS 40 subjects being ethnic Norwegians or of South Asian origin were randomized into an intervention or a control group. They were previously diagnosed as hyperglycemic, or with high risk of type 2 diabetes according to Ramachandran's risc score.
Control subjects were told to maintain their usual physical activity patterns during the study period, while the intervention subjects were instructed to undertake a minimum of 30 minutes of daily post-meal physical activity in addition to their usual activity patterns.
Venous blood samples were taken before and after the 12 week intervention period. Plasma was analyzed for HbA1c and for fasting and 2hour (OGTT) values of glucose, insulin and c-peptide. The subjects kept a physical activity diary, answered questionnaires and used accelerometers to determine the level of physical activity.
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Interventional
Not applicable
Lillehammer, 2618, Norway
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Adding a minimum of 30 minutes of physical activity starting maximum 30 minutes after the last meal daily
Time frame: Pre and post intervention which lasts an average of 12 weeks
Time frame: Pre and post intervention which lasts an average of 12 weeks
Time frame: Pre and post intervention which lasts an average of 12 weeks
Oral glucose tolerance test (OGTT)
Time frame: Pre and post intervention which lasts an average of 12 weeks
glucose measured by finger sticks every 15. minute during the 2hour oral glucose tolerance test
Time frame: Measured pre and post intervention which lasts an average of 12 weeks
Heart rate measured at the end of 10 minutes ergometer cycle test an given intensity (low) to moderate intensity)
Time frame: Measured pre and post intervention which lasts an average of 12 weeks
measured at the end of 10 minutes ergometer cycle test an given intensity (low) by indirect calorimetry
Time frame: Measured pre and post intervention which lasts an average of 12 weeks
Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry
Time frame: Measured pre and post intervention which lasts an average of 12 weeks
Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low)
Time frame: Measured pre and post intervention which lasts an average of 12 weeks
measured at the end of 10 minutes ergometer cycle test an given intensity (low) from capillary blod from a finger stick
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Time frame: Measured Pre and post intervention which lasts an average of 12 weeks
Quality of life measured by SF36
Time frame: Measured for 4 days pre intervention and 4 days in the middle of intervention
Measured by accelerometer
Time frame: Measured for 4 days pre intervention and 4 days in the middle of intervention
Measured by dietary registration with dietary diary and a kitchen scale
Inland Norway University of Applied Sciences
Other
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