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OpenTrials
Completed

NCT Number: NCT00223470

Cytokine Regulation of Periradicular Pain in Humans

This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis

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Key information

Conditions

Chronic Apical Periodontitis of Pulpal Origin Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

16 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Univerity of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

About this study

This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis with chronic apical periodontitis, but no pain or mechanical allodynia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient must be at least 16 years of age.
  • Clinical indication for Non-Surgical Root Canal Therapy (NSRCT).
  • 1st or 2nd maxillary or mandibular molar
  • Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms.
  • Intact, mature apices.
  • ASA I or II

Exclusion criteria

  • Failure to meet any of the above
  • Previous NSRCT
  • Previous pulpotomy or pulpectomy
  • Suppurative apical periodontitis
  • Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center at San Antonio

Other

Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)
  • National Institutes of Health (NIH)

Registry information

Important dates

Study start
2002
Primary completion
2008
Study completion
2008
First posted
Sep 22, 2005
Registry last updated
Mar 9, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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