CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α Cascad

Collect some tumor tissue specimens from patients who have undergone colorectal cancer surgery and conduct experiments such as immunohistochemistry to observe the expression of related genes in colorectal cancer.

Completed

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Key information

Conditions

Colorectal Cancer (CRC) Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230032, China

About this study

We need to collect postoperative specimens and adjacent normal tissue specimens from patients with colorectal cancer for immunohistochemical staining. There is no need to conduct any other grouping of the patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(1) Patients diagnosed with colorectal cancer who received surgical treatment and postoperative chemotherapy (2) Patients who were conscious of their condition and voluntarily participated (3) No other serious underlying diseases

Exclusion criteria

(1) Concurrent other serious chronic diseases or organ damage (2) Diagnosed with benign colorectal tumors

Treatment and study plan

Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

Other

Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

Primary outcomes

Immunohistochemical determination of the expression levels of related genes

Time frame: 2022.09-2025.09

Sponsors and collaborators

Lead sponsor

hui hou

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2025
Study completion: 2025
First posted: Sep 29, 2025
Registry last updated: Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed