Clinical Characteristics and Prognosis of Simultaneous Versus Delayed Resection for Synchronous Colorectal Liver Metastasis: A Nationwide Multicenter Study Utilizing Propensity Score Matching Analysis

Colorectal cancer (CRC) often metastasizes to the liver, with synchronous metastases observed in 20% of cases. Surgical resection is the primary treatment, but the impact of simultaneous and staged resections on clinical outcomes remains unclear. This study employs propensity score matching (PSM) in a nationwide survey to compare clinical characteristics, complications, and survival, providing valuable insights for optimizing the management of colorectal liver metastases.

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Key information

Conditions

Colorectal Cancer (CRC) Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Tenth People Hospital, Yanchang Road, Jingan District, Shanghai,

Shanghai, Jingan, 200040, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

a histologically confirmed diagnosis of colorectal cancer with liver metastases; and 2) age ≥ 18 years

Exclusion criteria

extrahepatic metastases; and 2) ineligibility for curative surgical resection based on preoperative assessment.

Treatment and study plan

Primary outcomes

overall survival

Time frame: 2 years
postoperative complications

Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Shanghai 10th People's Hospital

Other

Collaborators

RenJi Hospital

Registry information

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2024
First posted: Jul 24, 2025
Registry last updated: Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed