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Completed

NCT Number: NCT04439981

Curcuma Extract Beneficial for Muscle Damage

Muscle damage and inflammation is a clinical problem caused by the unimpeachable body adaptation of strenuous exercise through increasing free radicals. Antioxidants content in Curcuma is hypothesized to alleviate the free radicals. This study aimed to examine the effect of Curcuma extract in the form of ice cream to improve muscle damage and inflammation of soccer athletes caused by strenuous exercise. This study was experimental study with pre-post control group design. Male soccer athlete (n=20) were divided into treatment group (n=10) and control group (n=10). The treatment group was treated by Curcuma extract ice cream for 21 days. Blood samples of creatine kinase (as muscle damage marker) and IL-6 (as inflammation marker) were quantified.

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Key information

Age range

14 year–18 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Badan Pusat Pendidikan dan Pelatihan Olahraga Pelajar (BPPLOP) Semarang, Indonesia

Semarang, Provinsi, 50198, Indonesia

About this study

Muscle damage is a clinical problem caused by the adaptation process in strenuous exercise of soccer athletes which free radical is the main culprit of the damage. There is a significant increment of muscle damage after strength exercise using leg press. Physical exercise leads to inflammation process in endothelial cells of blood vessel which can be marked by releasing cytokine. Interleukin-6 (IL-6) is one of cytokine pro-inflammation and this marker is used as an indicator for inflammation of micro-trauma in muscle during strenuous exercise.

Normally, free radical generation will be stabilized by endogenous antioxidant secretion such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase; nevertheless, body needs exogenous antioxidant to support endogenous antioxidant as a scavenger of free radical in such condition.

Muscle damage due to the strenuous exercise should be managed to avoid the pain feeling and subsequently decrease athlete performances. Some previous studies used herbs such as ginger (Zingiber officinale), ginseng (Panax quinquefolium), and Curcuma to relieve the muscle damage and inflammation resulting from high-intensity exercise.The Curcuma extract treatment to the athlete gained lack of success; therefore, supplementation to food products might use to increase acceptability. Ice cream is one of the products, which has a broad segment market and every single person regardless of age is fond of it.

Curcumin is an antioxidant substance contained in Curcuma and it has better antioxidant capacity compared to the other component in Curcuma such as demetoksicurcumin and bisdemetoksicurcumin.Besides, curcumin has an efficient reaction with superoxide radicals as well as lipid antioxidants has, and the reaction leads to superoxide catalytic degradation in which curcumin represents as a superoxide dismutase. This study aimed to examine the Curcuma extract effect which has been supplemented to own-made ice cream in muscle damage and inflammation of soccer athletes after having strenuous exercise.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male
  • 14-18 year-old
  • does not have an acute and chronic
  • hemoglobin level ≥13 g/L
  • nutrition status normal (BMI >18.5-25.0)
  • no coffee consumption
  • no alcohol consumption
  • no drugs consumption
  • no smoking
  • no vitamin and other supplements consumption at least two weeks before this study was conducted
  • no additional exercise except the programmed exercise

Exclusion criteria

  • Subject did not comply the procedure of the study

Treatment and study plan

Ice cream

Dietary Supplement

Curcumin extract was added into ice cream

Primary outcomes

  1. Lactic acid change

    Time frame: 21 days

    Change from baseline lactic acid at 21 days taken in the lab from venous blood specimen using spectrophotometric method

  2. Hemoglobin change

    Time frame: 21 days

    Change from baseline hemoglobin at 21 days taken in the lab from venous blood specimen using cyanmethemoglobin method

  3. IL-6 change

    Time frame: 21 days

    Change from baseline IL-6 at 21 days taken in the lab from venous blood specimen using ELISA method

  4. Creatinine kinase change

    Time frame: 21 days

    Change from baseline creatinine kinase at 21 days taken in the lab from venous blood specimen using ELISA method

Sponsors and collaborators

Lead sponsor

Universitas Muhammadiyah Semarang

Other

Registry information

Official study title

Beneficial Effect of Curcuma Extract In Muscle Damage (Study in Soccer Athlete): Randomized Clinical Trial

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jun 19, 2020
Registry last updated
Jun 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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