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Completed

NCT Number: NCT01823094

CTP Imaging of Lung Cancer

Investigators hope to learn more about how to use computed tomography (CT) scans to measure blood flow in lung tumors and how it may change in response to treatment. This measurement technique is called computed tomography perfusion (CTP). CT scanners use X-rays to produce 3-dimensional images of the body.

Currently, doctors determine the response to treatment by measuring the size of the tumor. Investigators are trying to find out if measuring the blood flow in the tumor is equal to or better than measuring the size of the tumor.

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Key information

Conditions

Non Small Cell Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California, Davis Medical Center

Sacramento, California, 95817, United States

About this study

This is an experimental study of CT perfusion (CTP) imaging in subjects with non-small cell lung cancer. The objectives of this study are to demonstrate the feasibility of CT blood flow measurements in lung cancer, to develop a foundation for the use of CT blood flow measurements in lung cancer to assess the response to treatment, and to develop an optimized CTP imaging protocol for evaluating blood flow in solid body tumors. In this study, tumor blood flow will be evaluated at baseline and follow-up routine CT examinations of patients with non-small cell lung cancer, and the response of tumor blood flow will be recorded as a secondary endpoint. This research study will entail two study visits - one required and one optional - which will coincide with regularly scheduled standard of care CT scans.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult patients with non small cell lung cancer who receive, or are considered for, systemic therapy

Exclusion criteria

renal failure pregnancy known contrast allergy

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Treatment and study plan

Primary outcomes

  1. Yield of conducting CTP studies

    Time frame: 2 years

    Yield is determined as the percentage of assessable CTP studies, relative to all performed studies

Secondary outcomes

  1. Variability of CTP measurements

    Time frame: 2 years

    Variability will be determined from two consecutively acquired CTP examinations, and repeated analyses of the same studies

  2. Magnitude of treatment induced changes in tumor blood flow

    Time frame: 2 years

    The magnitude of treatment induced changes in blood flow will be determined from comparisons of bloodflow before and after treatment

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Collaborators

  • Radiological Society of North America

Registry information

Official study title

CTP (Computed Tomography Perfusion) Imaging of Lung Cancer

Acronym: CTPLC

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Apr 4, 2013
Registry last updated
Jan 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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