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NCT Number: NCT07664371

Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis

The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine, Tanta University

Tanta, Egypt

Location status: Recruiting

Location contact

Aliaa Mamdouh Abdelaziz Farag, MD

CONTACT

[email protected]

+201069468486

About this study

The main approach to OA management is pain control. Cryoneurolysis versus radiofrequency in decreasing knee pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults between the ages of 30 and 70 years with a clinical diagnosis of refractory knee OA who suffered from knee pain.
  • Patients who cannot afford intra-articular injections.
  • patients who had failed 2 different oral pain medications, and 6 weeks of physical therapy.

Exclusion criteria

  • Patients with OA show improvement in pain after physiotherapy.
  • patients evaluated by an orthopedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.
  • pregnant patients.
  • patients on anticoagulation therapy, who were not permitted to stop anticoagulation.
  • patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis.
  • people who had received an intra-articular knee injection within the last 6 months.
  • Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.

Treatment and study plan

Cryoneurolysis

Device

Cryoneurolysis freezes nerves

pulsed radiofrequency (RF)

Device

radiofrequency (RF) uses electric pulses

Cooled Radiofrequency

Device

uses cooled radiofrequency energy to deactivate pain-causing nerves

Primary outcomes

  1. Change in visual analogue scale after intervention

    Time frame: immediately after intervention

    Decrement (clinical improvement) in visual analogue scale (VAS) immediately after intervention. The participant's knee discomfort was measured using a VAS. Participants were asked to score their level of pain on a 100-mm horizontal line, ranging from 0 to 100.

Study contacts

Contact information is provided by the study sponsor or research team.

Aliaa Mamdouh Abdelaziz Farag, MD

CONTACT

[email protected]

+201069468486

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis: A Randomised Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 24, 2026
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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