Critical Care Ultrasound Guided Weaning

Weaning patients from the ventilator in the intensive care unit is sometimes difficult because of three main interrelated etiologies: impaired lung, heart or diaphragm function. In this context, ultrasonography performed during tests for extubation of patients may enable the diagnosis of cardiac dysfunction, loss of pulmonary aeration, diaphragm dysfunction, and venous congestion, thereby reducing the number of failures in extubation.

The combination of TTE (Trans Thoracic Echocardiography), LUS (Lung Ultrasound), DUS (Diaphragmatic ultrasound) and VEXUS (Venous excess Ultrasound) may enable the identification of the etiology of weaning failure and reduce the number of extubation failures by enabling the development of an appropriate treatment strategy. With this study, it is aimed to contribute to the literature in this sense.

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Key information

Conditions

Weaning Failure

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Antalya Training and Research Hospital

Antalya, 07059, Turkey (Türkiye)

About this study

The aim of this study is to reduce the number of extubation failures by defining the etiology of weaning failure and developing appropriate treatment strategies by using intensive care ultrasonography applications in combination (defining cardiac, pulmonary, diaphragmatic and venous congestion).

Most patients can be extubated after the first SBT (spontaneous Breathing Trial). A patient who fails extubation is automatically classified as difficult weaning, and intensive care professionals frequently encounter patients who are difficult to wean from mechanical ventilation.

Before performing a new SBT following a failed SBT, the cause of the failure should be determined and an appropriate treatment strategy developed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Invasive mechanical ventilation > 24 hours Eligibility to weaning from mechanical ventilation

Exclusion criteria

Age < 18 years old
Severe skin lesions or infections that cannot perform ultrasound
Severe subcutaneous emphysema that cannot perform ultrasound
Patients with a known neuromuscular disease
Patients with a duration of mechanical ventilation <24 hours,
Patients with severe mitral stenosis, severe mitral regurgitation, or prosthetic mitral valve

Treatment and study plan

Primary outcomes

Mechanical ventilation weaning success

Time frame: 48 hours

Weaning success: stable without mechanical ventilator support during more than 48 hours
Mechanical ventilation weaning failure

Time frame: 48 hours

Weaning failure: unstable without mechanical ventilator support within 48 hours

Secondary outcomes

Mortality

Time frame: ICU mortality after ultrasonography guided weaning

Incidence of ICU mortality

Sponsors and collaborators

Lead sponsor

Antalya Training and Research Hospital

Other Gov

Registry information

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Mar 10, 2023
Registry last updated: Jul 21, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed