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OpenTrials
Completed

NCT Number: NCT07083128

Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning

optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences

Completed

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Key information

Conditions

Mechanical Ventilation Weaning Failure Weaning From Mechanical Ventilation

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cairo University

Cairo, Cairo Governorate, 6890, Egypt

About this study

Several parameters were proposed to assess proper weaning time including diaphragmatic ultrasound and extra-diaghragmatic muscles. previous research concluded an ability of parasternal intercostal (PIC) thickening to predict weaning outcomes. researchers of current study assumed that temporal changes in PIC thickening would provide greater ability to predict weaning outcomes

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mechanically ventilated for 24 hours or more ready for weaning

Exclusion criteria

  • Refusal Tracheostomized Inability to obtain ultrasound views patients with neuromuscular disease

Treatment and study plan

Parasternal intercostal thickening

Device

Temporal change in parasternal intercostal thickening fraction at initiation and 30 minutes of spontaneous breathing trial

Primary outcomes

  1. Accuracy of change in PIC-TF in predicting successful weaning from mechanical ventilation

    Time frame: At baseline and 30 minutes after initiation of spontaneous breathing trial

    percentage of change in PIC TF in predicting weaning outcome (PIC TF30-PIC TF0)

Secondary outcomes

  1. Accuracy of change in PIC-TF to predict reintubation

    Time frame: At baseline and 30 minutes after initiation of spontaneous breathing trial

    percentage of change in PIC TF at start and end of spontaneous breathing trial (PIC TF30-PIC TF0)

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Temporal Changes in Parasternal Intercostal Muscle Thickening as a Possible Biomarker for Successful Weaning From Mechanical Ventilation: a Prospective Observational Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2025
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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