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Completed

NCT Number: NCT01564745

Cough Determinants in Mechanically Ventilated Patients

In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough. In order to determine some determinants of cough, the investigators propose to evaluate systematically different physiological parameters before and after extubation.

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Key information

Conditions

Mechanical Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital, Caen, Caen, France

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About this study

In order to evaluate, and identify the cough determinants, the investigators propose a physiological evaluation for each patients who were intubated and mechanically ventilated during at least 72 hours. Indeed inefficacy of cough after extubation is one of the main reason of extubation failure. However there is no any mean to evaluate it simply now.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients mechanically ventilated since 72h
  • Age > 18 years
  • Hospitalized in Intensive care Unit
  • In weaning phase - with the classically criteria to be extubated
  • Patients who passed the weaning test (T tube test or other)

Exclusion criteria

  • Hemodynamic instability
  • Absence of consent
  • No cooperation of the patient
  • Hemodynamic instability
  • pH < 7,30
  • Severe hypoxemia

Treatment and study plan

Functional respiratory evaluation

Other

Each enrolled patients has a pulmonary function test before and after extubation, and repeatedly at D1, D3, D5 (if they are always hospitalized)

Other names: Pulmonary Function test

Primary outcomes

  1. Interest of systematically cough evaluation before extubation

    Time frame: 2 days after extubation

    All the patients enrolled have a physiological evaluation before and after extubation. After extubation the evaluation will be done respectively at D0, D1, D3 and D5. The first endpoint is the success of extubation which is evaluated à D2.

Secondary outcomes

  1. Correlation between success of extubation and respiratory parameters

    Time frame: 2 days after extubation

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Collaborators

  • Centre d'Investigation Clinique et Technologique 805
  • Institut National de la Santé Et de la Recherche Médicale, France

Registry information

Official study title

Cough Determinants in Mechanically Ventilated Patients: a Physiological Study

Acronym: Extu-Cough

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Mar 28, 2012
Registry last updated
Apr 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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