Correlations of the Microvascular Abnormalities on NVC (Nail Fold Video Capillaroscopy) and GAVE (Gastric Antral Vascular Ectasia) as Seen on EGD

The purpose of this research is to determine whether a procedure called capillaroscopy can help distinguish patients who are diagnosed with GAVE (gastric antral vascular ectasia) with an autoimmune disease versus idiopathic/other conditions based on EGD findings.

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Key information

Conditions

Gastric Antral Vascular Ectasia Angiodysplasia Cardiovascular Diseases Digestive System Diseases Gastrointestinal Diseases Stomach Diseases Vascular Diseases

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic (Florida), Jacksonville, Florida, United States

About this study

The primary aim of this study is to define the prevalence and findings (as per quantification) of nail fold video capillaroscopy abnormalities in patients with GAVE. The secondary aim is to compare the findings of NVC and clinical presentation in patients with GAVE.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients 18 years and older with gave diagnosis as pair EGD performed in Gastroenterology as standard of care.

Patients with GAVE with connective tissue disease will be compared to patients with GAVE without a connective tissue disease.

Exclusion criteria

Age less than 18 years of age, pregnant individuals, dialysis dependent, type 2 diabetes, recent hand trauma or manicure (<2 weeks), routine use of vibratory tools, history of acrocyanosis or erythromelalgia, previous diagnosis of a bleeding disorder, diagnosis of psoriasis, diagnosis of anti-phospholipid syndrome, exposure to toluene or benzoyl, diagnosis of psoriasis, diagnosis of COPD.

Treatment and study plan

Video Capillaroscopy

Device

A non-invasive imaging technique used to assess capillary structure and morphology in the nailfold area, commonly used in evaluating microvascular changes associated with connective tissue diseases.

Other names: Nailfold Video Capillaroscopy

Primary outcomes

Prevalence and Phenotypic with G.A.V.E

Time frame: From enrollment to end of study once the accrual has been met within baseline of Day 1

Defined the prevalence and phenotype of nail fold video capillaroscopy abnormalities in patients with G.A.V.E.

Secondary outcomes

Comparing Findings

Time frame: From enrollment to end of study once the accrual has been met within baseline of day 1

To compare the findings of and VC and clinical manifestation and organ involvement patients with gave and connective tissue disease to those with gave without connective tissue disease.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Acronym: GAVE

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Aug 17, 2025
Registry last updated: Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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