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Completed

NCT Number: NCT04388150

Efficacy of Narrow Band Spectrum Endoscopy for the Diagnosis of Gastric Antral Vascular Ectasia in Patients With Liver Cirrhosis

the study aims to evaluate the role of similar technology of Narrow Band Imaging VIST video intelligent staining technology in the diagnosis of Gastric Antral Vascular ectasia in cirrhotic patients

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Key information

Conditions

Gastric Antral Vascular Ectasia Angiodysplasia Cardiovascular Diseases Digestive System Diseases Gastrointestinal Diseases Stomach Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Internal Medicine, Hepatology Unit. Faculty of Medicine, Alexandria University

Alexandria, Egypt

About this study

VIST (Video intelligent staining technology) is used to the diagnosis of GAVE as the form of ectatic vessels in the antrum in instead of erosions in the antrum by White light endoscopy which can mislead the diagnosis to Portal hypertension gastropathy. Targeted biopsies are taken and examined histopathologically in order to see if matching with VIST view. In addition, CD61 is used to highlight the diagnosis for more confirmation. CD61 is an immunohistochemistry platelets marker.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with mucosal vascular lesions at the gastric antrum suspicious of GAVE of a linear striped form or a diffuse punctate form upon conventional WLE

Exclusion criteria

  • Connective tissue disorders like systemic sclerosis.
  • Chronic kidney disease.
  • Recent use of proton pump inhibitors in the last 14 days.
  • History of gastric surgery or gastric cancer.
  • Pernicious anemia.
  • Recent history of non-steroidal anti-inflammatory drugs intake

Treatment and study plan

Upper gastrointestinal endoscopy and biopsy

Diagnostic Test

Gastroscope with technology of VIST video intelligent staining technology for taking biopsies

Primary outcomes

  1. Efficacy of Narrow Band Spectrum endoscopy for the diagnosis of Gastric antral vascular ectasia in cirrhotic patients

    Time frame: it is estimated to be 12 months

    It is done by the new technology of VIST which is similar to Narrow Band Imaging in the diagnosis of Gastric antral vascular ectasia in cirrhotic patients that were misdiagnosed before as portal hypertension gastropathy

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Efficacy of Narrow Band Spectrum Endoscopy Versus Histopathology for the Diagnosis of Gastric Antral Vascular Ectasia in Patients With Liver Cirrhosis

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
May 14, 2020
Registry last updated
Mar 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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