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Completed

NCT Number: NCT07693673

Corneal Topography and High Order Aberrations in Regular Contraceptive Pills

Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations

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Key information

Conditions

Cornea Corneal Diseases Eye Diseases Refraction Error Refractive Errors

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Ophthalmology Department, Sohag University Hospital, Faculty of Medicine, Sohag University

Sohag, Sohag Governorate, 82524, Egypt

About this study

Comparing corneal topographic changes and corneal high-order aberrations for women planning to use oral contaceptive pills before and after the usage of the pills

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female participants aged 18-40 years.
  • Prescribed combined oral contraceptive pills as part of routine gynecological care.
  • Willing to undergo corneal topography/tomography before starting treatment and after 1 year.
  • No previous history of corneal disease or ocular surgery.
  • Able to provide informed consent.

Exclusion criteria

  • Keratoconus or suspected corneal ectasia.
  • Corneal opacity, dystrophy, degeneration, or scarring.
  • Previous ocular surgery or significant ocular trauma.
  • Current contact lens use or recent contact lens use without adequate discontinuation period.
  • Active ocular surface disease or severe dry eye.
  • Glaucoma, uveitis, retinal disease, or other significant ocular pathology.
  • Diabetes mellitus, autoimmune disease, thyroid disease, pregnancy, or lactation.
  • Use of other hormonal therapy or systemic medications known to affect corneal parameters.

Treatment and study plan

Hormonal Contraception

Other

Effect of usage of hormonal contraceptive pills on corneal topography and corneal high-order aberrations

Combined Oral Contraceptive (COC)

Drug

Participants who are prescribed combined oral contraceptive pills as part of routine clinical care will be observed. Corneal topography and tomography will be performed before starting treatment and after the follow-up period to evaluate changes in corneal parameters.

Primary outcomes

  1. Change in K1 (D)

    Time frame: Baseline and 1 year

  2. Change in K2 (D)

    Time frame: one year

  3. Change in Kmax (D)

    Time frame: one year

  4. change in corneal thickness (um)

    Time frame: one year

Sponsors and collaborators

Lead sponsor

Elshimaa A.Mateen

Other

Registry information

Official study title

Corneal Topography and High Order Aberrations in Women on Regular Contraceptive Pills

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 9, 2026
Registry last updated
Jul 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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