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Completed

NCT Number: NCT03808571

Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

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Key information

Conditions

Nesfatin-1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Female Urogenital Diseases and Pregnancy Complications Fetal Diseases Fetal Growth Retardation Growth Disorders Intrauterine Growth Restriction Irisin Pathologic Processes Pathological Conditions, Signs and Symptoms Pregnancy Complications Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Yuzuncu Yil University, Medical faculty, department of obstetric and gynecology

Van, 65000, Turkey (Türkiye)

About this study

This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant women with intrauterine grwoth rectricted fetuses.
  • Healthy pregnancies

Exclusion criteria

  • Pregnant women with chronic medical conditions
  • multiple pregnancies
  • fetuses with fetal malfomations or genetic syndromes
  • pregnant women older than 45 years old

Treatment and study plan

cord blood specimen during the delivery

Other

The cord blood will be taken during the delivery of baby.

Primary outcomes

  1. cord blood nesfatn-1 level measurement

    Time frame: 9 months

    cord blood levels of nesfatin-1 in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

Secondary outcomes

  1. Cord blood irisin level measurement

    Time frame: 9 months

    ord blood levels of irisin in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

Sponsors and collaborators

Lead sponsor

Yuzuncu Yil University

Other

Registry information

Official study title

The Association of Cord Blood Nesfatin-1 and Irisin Level With Fetal Doppler Parameters in Pregnancies Complicated With Intrauterine Growth Restricted Fetuses

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jan 17, 2019
Registry last updated
Jan 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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