Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression

Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.

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Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medicine

Gaziantep, Şehitkamil, 27310, Turkey (Türkiye)

About this study

Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Migraine

Exclusion criteria

Vascular problems

Treatment and study plan

Migraine CNV

Genetic

Copy number variation effect on migraine disease

Primary outcomes

CNV number

Time frame: 1 year

CNV number effect on migraine

Sponsors and collaborators

Lead sponsor

University of Gaziantep

Other

Registry information

Official study title

Copy Number Variation in Migraine and Gene Expression

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2021
First posted: Jun 3, 2021
Registry last updated: Jun 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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