Consequences of Hypoglycemia on Intensive Care Unit (ICU) Patients

Hypoglycemia occurs frequently during intensive blood glucose control in critically ill patients. The incidence of hypoglycaemia is associated with impaired outcome. However, it is hitherto unknown if hypoglycaemia itself predisposes patients to neurological impairment, e.g. cognitive dysfunction, or if it is the underlying medical condition that makes the patient prone to a high risk of hypoglycaemia and, concomitantly, neurocognitive impairment. Therefore we investigate neurocognitive function in patients who had hypoglycemias during their intensive care stay and compare the results to patients without hypoglycaemia whose medical conditions are matched to the hypoglycaemia patients.

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Key information

Conditions

Critical Illness Cognition Disorders Disease Attributes Glucose Metabolism Disorders Hypoglycemia Mental Disorders Metabolic Diseases Neurocognitive Disorders Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology and Intensive Care, University Hospital Münster

Münster, D-48149, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

all patients

Exclusion criteria

clinical diagnosis of diabetes mellitus
brain injury of any kind prior to or upon ICU-admission
pre-existing mental or psychiatric disorder
terminal kidney or liver failure prior admission
drug abuse,
CPR > 5 min
HIV
Lues

Treatment and study plan

Primary outcomes

neurocognitive function

Time frame: 1 year after ICU discharge

Secondary outcomes

neurocognitive function

Time frame: 2,3, and 4 years after ICU discharge

Sponsors and collaborators

Lead sponsor

University Hospital Muenster

Other

Registry information

Official study title

Does Hypoglycemia Under Intensive Insulin Therapy During Critical Illness Lead to Neurocognitive Dysfunction

Important dates

Study start: 2008
Primary completion: 2008
Study completion: 2008
First posted: Apr 21, 2008
Registry last updated: Jan 11, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed