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Completed

NCT Number: NCT02834845

Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension

Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation. On this account, the investigators aim to investigate the effects of different volatile anesthetics combined with a short-acting opioid on cerebral oxygenation during controlled hypotension using near infrared spectroscopy.

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Key information

Conditions

Oxygen Saturation

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ufuk University Hospital

Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients in American Society of Anesthesiology (ASA) classification I and II
  • Patients undergoing elective septoplasty operation

Exclusion criteria

  • Patients in ASA classification III and higher
  • Emergency surgery
  • Patients in New York Heart Association classification III-IV
  • Patients with known allergy to drugs used in the study

Treatment and study plan

Sevoflurane

Drug

Sevoflurane %2-3 for general anesthesia maintenance

Desflurane

Drug

Desflurane %6-8 for general anesthesia maintenance

Primary outcomes

  1. Cerebral oxygen saturation as measured by Near Infrared Spectroscopy

    Time frame: Duration of surgery

    The effect of sevoflurane and desflurane on NIRS values

Secondary outcomes

  1. Total remifentanil consumption as measured in micrograms

    Time frame: Duration of surgery

  2. The effect of anesthetics on hemodynamic variables

    Time frame: Duration of surgery

    The effects of sevoflurane and desflurane on mean arterial pressure

  3. The effect of anesthetics on hemodynamic variables

    Time frame: Duration of surgery

    The effects of sevoflurane and desflurane on heart rate

  4. The effect of anesthetics on hemodynamic variables

    Time frame: Duration of surgery

    The effects of sevoflurane and desflurane on bispectral index

Sponsors and collaborators

Lead sponsor

Ufuk University

Other

Registry information

Official study title

Comparison of Effects of Sevoflurane and Desflurane on Cerebral Oxygenation During Controlled Hypotension

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jul 15, 2016
Registry last updated
Aug 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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